From NYTimes.com:
In the early 1960s composers who had been fascinated with electronic music in the ’50s were seeking ways to combine the synthetic sounds they were producing on room-size computers and early synthesizers with the more familiar timbres of acoustic instruments. The Argentine-born American composer Mario Davidovsky, then in his late 20s, was a star of this movement: his “Synchronisms No. 1,” for flute and electronic sound, appeared in 1962, and new installments turned up periodically through 2006, when he wrote “Synchronisms No. 12,” for clarinet and tape.